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APR-246 and inhibitors of the cystine/glutamate antiporter, system x C , take advantage of this vulnerability to selectively kill mut-p53 cancer cells

Recommendations It is recommended that the total antioxidant capacity should be done to show the cumulative impact between stress exposure rate and duration of stress on levels of GSH, GST and GPx of the overall kidney, ovary, liver and brain cellular defence system in redox state for the different stress model studied for a clearer understanding of the synergistic mechanism involved

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